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- John Lackey, P, Anaheim Angels
- Pete Laforest, C, Tampa Bay Devil Rays
- Gerald Laird, C, Texas Rangers
- Mike Lamb, 1B, Houston Astros
- Chris Lambert, P, St. Louis Cardinals
- Chase Lambin, 2B, New York Mets
- Jason Lane, RF, Houston Astros
- Ryan Langerhans, RF, Atlanta Braves
- Adam Laroche, 1B, Atlanta Braves
- Andy Laroche, 3B, Los Angeles Dodgers
- Jason Larue, C, Cincinnati Reds
- Brian Lawrence, P, Washington Nationals
- Matt Lawton, RF, Seattle Mariners
- Brandon League, P, Toronto Blue Jays
- Francisco Leandro, LF, Tampa Bay Devil Rays
- Matt Lecroy, DH, Washington Nationals
- Ricky Ledee, LF, Los Angeles Dodgers
- Wil Ledezma, P, Detroit Tigers
- Carlos Lee, LF, Milwaukee Brewers
- Cliff Lee, P, Cleveland Indians
- David Lee, P, St. Louis Cardinals
- Derrek Lee, 1B, Chicago Cubs
- Seung Lee, P, Philadelphia Phillies
- Travis Lee, 1B, Tampa Bay Devil Rays
- Justin Lehr, P, Milwaukee Brewers
- Jon Leicester, P, Texas Rangers
- Al Leiter, P, New York Yankees
- Matt Lemanczyk, LF, St. Louis Cardinals
- Anthony Lerew, P, Atlanta Braves
- Jon Lester, P, Boston Red Sox
- Fred Lewis, CF, San Francisco Giants
- Richard Lewis, 2B, Chicago Cubs
- Brad Lidge, P, Houston Astros
- Cory Lidle, P, Philadelphia Phillies
- Jon Lieber, P, Philadelphia Phillies
- Mike Lieberthal, C, Philadelphia Phillies
- Ted Lilly, P, Toronto Blue Jays
- Jose Lima, P, Kansas City Royals
- Mike Lincoln, P, St. Louis Cardinals
- Adam Lind, LF, Toronto Blue Jays
- Todd Linden, RF, San Francisco Giants
- Shane Lindsay, P, Colorado Rockies
- Matt Lindstrom, P, New York Mets
- Scott Linebrink, P, San Diego Padres
- Ray Liotta, P, Chicago White Sox
- Francisco Liriano, P, Minnesota Twins
- Pedro Liriano, P, Philadelphia Phillies
- Wes Littleton, P, Texas Rangers
- Bobby Livingston, P, Seattle Mariners
- Radhames Liz, P, Baltimore Orioles
- Esteban Loaiza, P, Oakland Athletics
- Paul Loduca, C, New York Mets
- Kameron Loe, P, Texas Rangers
- Adam Loewen, P, Baltimore Orioles
- Kenny Lofton, CF, Los Angeles Dodgers
- Nook Logan, CF, Detroit Tigers
- Kyle Lohse, P, Minnesota Twins
- James Loney, 1B, Los Angeles Dodgers
- Terrence Long, LF, Kansas City Royals
- Braden Looper, P, St. Louis Cardinals
- Aquilino Lopez, P, Philadelphia Phillies
- Felipe Lopez, SS, Cincinnati Reds
- Javy Lopez, C, Baltimore Orioles
- Jose Lopez, 2B, Seattle Mariners
- Pedro Lopez, SS, Chicago White Sox
- Rodrigo Lopez, P, Baltimore Orioles
- Mark Loretta, 2B, Boston Red Sox
- Derek Lowe, P, Los Angeles Dodgers
- Mike Lowell, 3B, Boston Red Sox
- Jed Lowrie, SS, Boston Red Sox
- Noah Lowry, P, San Francisco Giants
- Chris Lubanski, CF, Kansas City Royals
- Julio Lugo, SS, Tampa Bay Devil Rays
- Hector Luna, 2B, St. Louis Cardinals
- Brandon Lyon, P, Arizona Diamondbacks
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